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Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response
Lin, Chun-Yang, Wolf, Joshua, Brice, David C.; Sun, Yilun, Locke, Macauley, Cherry, Sean, Castellaw, Ashley H.; Wehenkel, Marie, Crawford, Jeremy Chase, Zarnitsyna, Veronika I.; Duque, Daniel, Allison, Kim J.; Allen, E. Kaitlynn, Brown, Scott A.; Mandarano, Alexandra H.; Estepp, Jeremie H.; Team, Sjtrc Study, Taylor, Charles, Molina-Paris, Carmen, Schultz-Cherry, Stacey, Tang, Li, Thomas, Paul G.; McGargill, Maureen A..
Cell host & microbe ; 2021.
Article in English | EuropePMC | ID: covidwho-1564429

ABSTRACT

A major unresolved question is whether prior immunity to endemic, human common cold coronaviruses (hCCCoV) impacts susceptibility to SARS-CoV-2 infection. Lin et al. analyze hCCCoV antibodies in the same individuals before and after SARS-CoV-2 infection, finding pre-existing betacoronavirus antibodies may hinder SARS-CoV-2 effective immunity following infection.

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